Fusion protein corresponding to residues near the C terminal of human ATP citrate lyase
Conjugate
Unconjugated
Applications
Application Notes
IHC: 1:50-1:200
General Notes
This product (Catalog No. DPABH-05757) is a rabbit-derived IgG polyclonal antibody raised against human ACLY. It has been affinity purified by protein A. ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. DPABH-05757 is suitable for use in IHC (1:50–1:200) application. DPABH-05757 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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