WH-250 N-pentanoic acid Standard Solution

Target

JWH-250

Tag/Conjugate

Unconjugated

Molecular Weight

365.4 g/mol

Alternative Names

1-pentyl-3-(2-methoxyphenylacetyl)indole

Format

Liquid

Concentration

1 μg/mL

Buffer

20mM sodium phosphate, 150mM NaCl, pH7.4

Preservative

None

Storage

Store at -20°C to -80°C

Introduction

JWH-250 or (1-pentyl-3-(2-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11 nM at CB1 and 33 nM at CB2. Unlike many of the older JWH series compounds, this compound does not have a naphthalene ring, instead occupying this position with a 2'-methoxy-phenylacetyl group, making JWH-250 a representative member of a new class of cannabinoid ligands. Other 2'-substituted analogues such as the methyl, chloro and bromo compounds are also active and somewhat more potent.

Keywords

JWH-250; 1-pentyl-3-(2-methoxyphenylacetyl)indole; Cannabinoid agonist