Product Overview
1.0 mg/mL analytical Valproic acid Standard
Molecular Weight
144.21g/mol
Alternative Names
Valproic acid; VPA
Application Notes
Standards in ELISA
Storage
Store unopened in freezer(-10°C to 25°C)
Introduction
Valproic acid, valproate sodium and divalproex belong to the group of medicines called anticonvulsants, used to control certain types of seizures in the treatment of epilepsy. Also, valproic acid relieves histone deacetylases (HDACs) dependent transcriptional repression and causes hyperacetylation of histones in cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro, most probably by binding to the catalytic centre of HDACs. Most importantly, valproic acid induces differentiation of carcinoma cells, transformed haematopoietic progenitor cells and leukaemic blasts from acute myeloid leukaemia patients. Moreover, tumour growth and metastasis formation are significantly reduced in animal experiments. Therefore, valproic acid might serve as an effective drug for cancer therapy.
Keywords
Valproic acid; VPA; Convulex; Depakene; Epilim; Ergenyl; Mylproin; valproate; Valproesαure; Valproic
Citations
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WILLIAMS, AM; WORRALL, S; et al. STUDIES ON THE REACTIVITY OF ACYL GLUCURONIDES .3. GLUCURONIDE-DERIVED ADDUCTS OF VALPROIC ACID AND PLASMA-PROTEIN AND ANTI-ADDUCT ANTIBODIES IN HUMANS. BIOCHEMICAL PHARMACOLOGY 43:745-755(1992).
ten Cate, B; Samplonius, DF; et al. The histone deacetylase inhibitor valproic acid potently augments gemtuzumab ozogamicin-induced apoptosis in acute myeloid leukemic cells. LEUKEMIA 21:248-252(2007).
COA
Certificate of Analysis
