Suitable for use to measure free Trastuzumab in patient samples.
Recommended antibody pair for pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB256 - CABT-ZB257
Recommended Working Concentration: 0.01-0.1 μg/ml
Summary
Specifications
Antibody Isotype
IgG2a, κ
Clone
22D5
Immunogen
Trastuzumab
Conjugate
Unconjugated
Applications
Application Notes
Suitable for use in PK bridging ELISA. We recommend the following for sandwich ELISA (Capture - Detection): CABT-ZB256 - CABT-ZB257 Recommended Working Concentration: 0.01-0.1 μg/ml
General Notes
We recommend the following antibody pair to develop a pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB256 - CABT-ZB257 CABT-ZB256 is recommended for use as a capture antibody when paired with CABT-ZB257 as a detection antibody. Trastuzumab with the brand name Herceptin, is an FDA-approved drug for HER2-targeted therapy for breast cancer. It is a recombinant humanized monoclonal antibody (IgG1 kappa). Trastuzumab binds to HER2 receptor present on the surface of HER2-positive tumour cells and suppresses the cells growth and proliferation.
Target
Alternative Names
Mouse monoclonal antibody to Herceptin; Trastuzumab; Herclon; Herceptin; Anti-Her2 antibody
Citations
Publication ()
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