Histone H2AX is a histone variant that is incorporated into a subset of nucleosomes in place of canonical histone H2A. H2AX is phosphorylated on serine 139 by the ATM and ATR kinases in response to DNA double strand breakage. Phosphorylated H2AX serves as a platform to recruit a number of DNA damage repair proteins, including BRCA1, NBS1 and MDC1.
Keywords
Histone; H1; H2A; H2B; H3; H4; Drug-induced lupus; DIL
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