Histone Antigen (DAG-T1215)

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Product Overview
Purified from bovine thymus. After coating onto ELISA plates the product will bind autoantibodies to histone antigen.
Target
Histone
Purity
The histone autoantigen is more than 90% pure, as assessed by SDS gel electrophoresis.
Concentration
0.5 -2.0 mg/ml
Size
0.20 mg
Storage
The product is stabilised with 0.1% Micr-O-protect TM. Store at -20°C or below (long term) or at +4°C (short term). Avoid repeated freezing and thawing. Mix thoroughly before use.
Introduction
In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes. They are the chief protein components of chromatin, acting as spools around which DNA winds, and play a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long (a length to width ratio of more than 10 million to 1 in human DNA). For example, each human cell has about 1.8 meters of DNA, but wound on the histones it has about 90 micrometers (0.09 mm) of chromatin, which, when duplicated and condensed during mitosis, result in about 120 micrometers of chromosomes.
Keywords
Histone;Histone Antigen;

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