Molecular Weight
45.5 kDa
Purity
> 95% as determined by HPLC
Buffer
Lyophilized from 0.22um filtered solution in PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization
Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week
Reconstitution
Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Introduction
The adenosine A2A receptor, also known as ADORA2A, is an adenosine receptor, and also denotes the human gene encoding it. The gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G protein-coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase, which induce synthesis of intracellular cAMP. The A2A receptor binds with the Gs protein at the intracellular site of the receptor. The Gs protein consists of three subunits; Gsα, Gsβ and Gsγ.
Keywords
Adenosine-A2A Receptor; ADORA2A; A2AR
Citations
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Hausler, SFM; del Barrio, IM; et al. Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 6:129-139(2014).
Lu, M; Farnebo, LO; et al. Inhibition of Parathyroid Hormone Secretion by Caffeine in Human Parathyroid Cells. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 98:E1345-E1351(2013).
COA
Certificate of Analysis
