Product Overview
This antigen is a recombinant HBcAg with a polyspherical conformation. Can effectively capture the anti-HBAg antibody in the test sample. It has excellent specificity, sensitivity and stability.
Molecular Weight
Monomer: 20KD; Spherical polymer: about 2200kD
Alternative Names
Hepatitis B Virus Core Antigen; HBcAg; HBV
Storage
Store at 2°C to 8°C.
Introduction
Hepatitis B Virus (HBV) infection inducesa disease state characterised by liver damage, inflammation and viralpersistence. Infection also increases the risk of hepatocellular carcinoma.HBV belongs to the Hepadnaviridae family of viruses. Its genome consists ofpartially double stranded circular DNA. The DNA is enclosed in anucleocapsid, or core antigen (HBcAg), which is surrounded by a sphericalenvelope (surface antigen or HBsAg). The core antigen shares its sequenceswith the e antigen (HBeAg) but no cross reactivity between the two proteinshas been observed. The HBV genome also encodes a DNA polymerase that alsoacts as a reverse transcriptase.
Keywords
Hepatitis B Virus Core Antigen; HBcAg; HBV
Citations
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Wu, J; Huang, SM; et al. Poly(I:C) Treatment Leads to Interferon-Dependent Clearance of Hepatitis B Virus in a Hydrodynamic Injection Mouse Model. JOURNAL OF VIROLOGY 88:10421-10431(2014).
Li, J; Han, YP; et al. DYNAMIC CHANGES AND CLINICAL SIGNIFICANCE OF HBCAG SPECIFIC CYTOTOXIC T LYMPHOCYTES IN PATIENTS WITH ACUTE HEPATITIS B. HEPATOLOGY 52:988A-988A(2010).
COA
Certificate of Analysis
