Product Overview
C-terminal 6xHis tagged HBcAg (HBV) protein (a.a. 1-149)
Purity
> 95%, based on SDS PAGE
Format
Each vial contains 100 μg of lyophilized protein in PBS with 8M Urea.
Storage
2-8°C short term, -20°C long term
Introduction
An antigen of the DNA core of the hepatitis B virus, indicating the presence of replicating hepatitis B virus. The nucleocapsid of the Hepatitis B virus (HBV) is extremely immunogenic. The icosahedral nucleocapsid is composed of 180 or 240 subunits of a 183-residue protein that is known as the HBV core (HBc) antigen (HBcAg). The subunits are clustered as dimers, producing spikes that protrude from the underlying shell domain, and contain the immunodominant loop of HBcAg. HBc antigen (HBcAg) capsids can activate naive B cells by cross-linking their surface receptors.
Keywords
C; Capsid protein; core; Core antigen; Core protein; HBcAg; Hepatitis B core antigen; p21.5; 5730409E04Rik
Citations
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Zhang, L; Meng, HX; et al. The relationship between HBV serum markers and the clinicopathological characteristics of hepatitis B virus-associated glomerulonephritis (HBV-GN) in the northeastern chinese population. VIROLOGY JOURNAL 9:-(2012).
Delladetsima, I; Papatheodoridis, GV; et al. Significance of liver histology in HBsAg-positive, IgM anti-HBc-negative acute hepatitis B virus-related hepatitis. HISTOPATHOLOGY 61:881-888(2012).
COA
Certificate of Analysis
