Mouse Anti-Human Parathyroid Hormone (PTH) monoclonal antibody, clone JID756

The protective effect of obesity on bone health has been challenged by studies that link visceral adiposity to poor bone microarchitecture in young obese men and women. In postmenopausal women, the role of visceral adipose tissue (VAT) on bone turnover markers (BTMs) has not been investigated. The aim was to investigate the impact of VAT on BTMs, total bone mineral density (BMD), vitamin D metabolites and parathyroid levels (1-84 PTH) levels in postmenopausal women. A total of 76 lean and overweight women (without osteoporosis) underwent VAT measurements by dual-energy X-ray absorptiometry (iDXA). Blood samples were analyzed for serum C-terminal telopeptide of type 1 collagen (CTX-1), osteocalcin, bone-specific alkaline phosphatase (bone ALP), 1-84 PTH and vitamin D (25 hydroxyvitamin D, 25(OH)D) levels. VAT volumes ranged from 91 to 3392 cm(3) and body mass index (BMI) ranged from 18.3 to 53.9 kg/m(2). Women in the highest VAT quartile had significantly lower CTX-1, 25(OH)D, osteocalcin and the highest BMD (p < 0.05, for all). While VAT positively associated with BMD, after controlling for BMI, VAT was a negative predictor of BMD (beta = 0.368, p < 0.05). VAT was an independent negative predictor of CTX-1 (beta = -0.263, p < 0.05) and osteocalcin levels (beta = -0.277, p < 0.05). Among all measures of adiposity, VAT was the strongest independent determinant of BMD and BTMs. In clinical settings, VAT, and not BMI, may be a sensitive predictor of bone health in obese women.

The effect of g-C3N4 on the sensing performance of a Pt/g-C3N4/ polythiophene nanocomposite (Pt/g-C3N4 /PTh NCs) was investigated in this work. The nanocomposites were synthesized via the chemical reduction of Pt (II) in the presence of L-cysteine as the reducing agent. The synthesized nanocomposite was utilized as a sensing material for the electrochemical detection of Hg2+ and was investigated by electrochemical impedance spectroscopy (EIS), cyclic voltammetry and differential pulse voltammetry. The electrical resistance from EIS measurements showed a decrease of 61.87 kohm. cm(- 2) for the Pt/PTh NCs compared to the Pt/g-C3N4 /PTh NCs, due to the increase of Pt adsorption onto the active sites of g-C3N4 and PTh. A linear voltammetric response was obtained between a concentration range of 1 and 500 nM Hg2+, with a detection limit (at S/N = 3) and sensitivity of 0.009 nM and 1.0787 mu A nM(-1). cm(-2), respectively.