Mouse Anti-Human PSA monoclonal antibody, clone JID765

Background Testing for prostate-specific antigen (PSA) levels in blood are widely used and associated with prostate cancer risk and outcome. After puberty, PSA levels increase by age and multiple single nucleotide polymorphisms (SNPs) have been found to be associated with PSA levels. However, the relationship between the effects of SNPs and age on PSA remains unknown. Methods To test for SNP x age interaction, we conducted a genome-wide association study using 2394 men without prostate cancer diagnosis from Malmo, Sweden as a discovery set and 2137 men from the eMERGE study (USA) for validation. Linear regression was used to identify significant interactions between SNP and age (p < 1 x 10(-4)for discovery,p < .05 for validation). Results The 15 SNPs from three different loci (8p11.22, 8p12, 3q25.31) are found to have age-specific effect on PSA levels. Expression quantitative trait loci (eQTLs) analysis shows that 12 SNPs from 3q25.31 locus affect the expression level of three genes: KCNAB1, SLC33A1, PLCH1. Conclusions Our results suggest that SNPs may have age-specific effect on PSA levels, which provides new direction to study genetic markers for PSA.

The effects of operating temperature on the performance of small scale oxygen concentrator were experimentally investigated using a rotary valve multi-column rapid cycle pressure swing adsorption (PSA) unit which produced a continuous stream of >= 90% O-2 from compressed air. Simple cooling fans and air cylinder were used for controlling the temperature of compressed air. The change of column midpoint gas temperature inside adsorption column wasrelatively small and approximately 3-5 K with a low pressure ratio of similar to 250:101 kPa during each cycle. The oxygen recovery could be improved by increasing the operating temperature and the bed size factor (BSF) could be reduced by decreasing the operating temperature. However, the adverse thermal effects on oxygen recovery and BSF became more dominant at very low and high operating temperatures. A similar trend between unit power and BSF at different operating temperature was emerged. There was an appropriate temperature range for achieving favorable performance.