Bordetella pertussis; B. pertussis; PT; B. pertussis toxin
Format
Liquid
Buffer
20mM PBS pH7.0
Preservative
None
Storage
Store at 4°C.
Introduction
Bordetella pertussis is a gram-negative, aerobic bacterium that causes whooping cough. Infection by B. pertussis mostly occurs in children who have not yet been immunised or have lost immunity in their teens. The symptoms of infection are similar to a common cold, including a runny nose, sneezing, cough and fever. If symptoms worsen, a more severe cough with a whooping sound is common, hence the name. Pertussis toxin (PTX) is a key toxin produced by B. pertussis to modulate immune responses that aid invasion and immune evasion. PTX is a 105kDa oligomer composed of 6 subunits (named S1-5, with two copies of S4), making it one of the most complex bacterial toxins identified. The subunits are organised in an A-B structure, whereby S1 comprises the enzymatic A domain and subunits S2-5 comprise the B domain in a pentameric ring.
Keywords
Bordetella pertussis; B. pertussis; PT; B. pertussis toxin
Citations
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