This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer"s and Parkinson"s disease. Two transcript variants encoding different isoforms have been found for this gene. Mouse monoclonal antibody raised against a full length recombinant UBQLN1.
Pathway
CXCR4-mediated signaling events, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem
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Q: Which research studies are suitable for the Anti-UBQLN1 Monoclonal antibody, clone 2D7-B4?
A: The Anti-UBQLN1 Monoclonal antibody, clone 2D7-B4 can be used WB, IF, sELISA, ELISAstudies .
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