Anti-UBQLN1 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human UBQLN1 is used for rabbit immunization.

Conjugate

Alternative Names

UBQLN1; ubiquilin 1; ubiquilin-1; DA41; DSK2; PLIC 1; XDRP1; hPLIC-1; protein linking IAP with cytoskeleton 1; UBQN; PLIC-1; FLJ90054;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimers and Parkinsons disease. Two transcript variants encoding different isoforms have been found for this gene.

Pathway

CXCR4-mediated signaling events, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem;