Anti-IL1RAP monoclonal antibody, clone 3B4

Antibody Isotype

IgG2b

Clone

3B4

Species Reactivity

Human

Immunogen

IL1RAP (AAH53621, 1 a.a. ~ 357 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

interleukin 1 receptor accessory protein; OTTHUMP00000209486; C3orf13; OTTHUMP00000209487; IL-1RAcP; OTTHUMP00000209488; IL1R3; OTTHUMP00000209489; Interleukin-1 receptor 3; OTTHUMP00000209490; IL-1R-3; OTTHUMP00000209491; IL-1R3; OTTHUMP00000209492; IL-1

Entrez Gene ID

UniProt ID

Antigen Description

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
Mouse monoclonal antibody raised against a full-length recombinant IL1RAP.

Pathway

Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL-1 Signaling Pathway, organism-specific biosystem