Product Overview
IL1RAP ( C - term ) peptide ( human )
Tag/Conjugate
Unconjugated
Application Notes
Stable for one year.
Buffer
Preservative: 0.02% Sodium Azide; Constituents: 0.1% BSA, PBS. pH 7.2
Preservative
0.02% Sodium Azide
Antigen Description
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]
Function
interleukin-1 receptor activity; receptor activity; signal transducer activity; transmembrane signaling receptor activity;
Synonyms
IL1RAP; interleukin 1 receptor accessory protein; interleukin-1 receptor accessory protein; C3orf13; IL 1RAcP; IL1R3; IL-1R3; interleukin-1 receptor 3; IL-1 receptor accessory protein; interleukin-1 receptor accessory protein beta; IL-1RAcP; FLJ37788;
Citations
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Askmyr, M; Agerstam, H; et al. Selective killing of candidate AML stem cells by antibody targeting of IL1RAP. BLOOD 121:3709-3713(2013).
Jaras, M; Johnels, P; et al. ISOLATION AND KILLING OF CANDIDATE CML STEM CELLS BY ANTIBODY TARGETING OF IL1RAP. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 95:242-242(2010).