Anti-IL1RAP (aa 525-540) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

a peptide corresponding to amino acids 525-540 of human IL-1RAcP, which is identical to mouse and rat origins.

Conjugate

Alternative Names

IL1RAP; interleukin 1 receptor accessory protein; IL1R3; C3orf13; IL-1RAcP; interleukin-1 receptor accessory protein; IL-1R3; interleukin-1 receptor 3; IL-1 receptor accessory protein; interleukin-1 receptor accessory protein beta

Entrez Gene ID

UniProt ID

Antigen Description

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]

Pathway

Apoptosis; Cytokine Signaling in Immune system; Cytokine-cytokine receptor interaction; IL-1 Signaling Pathway; Immune System; Inflammatory mediator regulation of TRP channels; Interleukin-1 signaling; Signaling by Interleukins