Anti-HMGA1 monoclonal antibody, clone 3B2

Antibody Isotype

IgG2b

Clone

3B2

Species Reactivity

Human

Immunogen

HMGA1 (NP_665906, 1 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

high mobility group AT-hook 1; HMGIY; MGC12816; high-mobility group (nonhistone chromosomal) protein isoforms I and Y; MGC4242; High mobility group AT-hook protein 1; MGC4854; High mobility group protein A1; OTTHUMP00000016223; High mobility group protein

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.
Mouse monoclonal antibody raised against a partial recombinant HMGA1.

Pathway

2-LTR circle formation, organism-specific biosystem; APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Autointegration results in viral DNA circles, organism-specific biosystem; Early Phase of HIV Life Cycle, organism-specific biosystem; HIV Infection, organism-specific biosystem.