General Notes
This product (Catalog No. DPABH-15857) is a rabbit-derived polyclonal antibody raised against human HMGA1, targeting the amino acid region 2–77 of the protein. This antibody exhibits cross-reactivity with Human HMGA1 from mouse. It has been affinity purified by Protein A. HMGA1, the high mobility group A1, encodes an oncofoetal protein that remodels the chromatin structure and promotes the interaction between transcriptional regulatory proteins and DNA in different cancers (PMID:8414980, PMID:11406267). The isoforms HMGA1a and HMGA1b can cross link DNA fibers in vitro and induce chromatin clustering in vivo (PMID:21596776). Mice lacking variant of HMGA1 are diabetic, show a cardiac hypertrophy and low levels of the insulin receptor (PMID:19664187). HMGA1 protein is mainly located in nucleus, especially in heterochromatin. HMGA1 is up-regulated in many tumours, including epithelial and mesenchymal tissue-originated tumours (PMID:30614613).
DPABH-15857 is suitable for use in Western blot (WB) (1:5,000–1:50,000), IHC (1:50–1:500), IF/ICC (1:50–1:500) applications.
DPABH-15857 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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