Distal-type bronchiolar adenoma of the lung harboring anEGFR exon 21 p.L858Rmutation: A case report
THORACIC CANCER
Authors: Yang, Chenglin; Wang, Xiaoliang; Da, Jiping; Ma, Kai
Abstract
Here, we present a case of a distal-type bronchiolar adenoma (BA) of the lung. BAs are benign lung tumors characterized by nodular proliferation of bilayered bronchiolar-type epithelium with a continuous layer of basal cells. This patient underwent S3 segmentectomy following detection by computed tomography (CT) scan of a gradually enlarging ground-glass nodule (GGO) over a five month period. Nodule morphology and immunophenotype were consistent with those of distal-type BA of the lung. An epidermal growth factor receptor (EGFR)exon 21 p.L858Rmissense mutation was identified which, to the best of our knowledge, is the first case to be reported of a common gene mutation associated with non-small cell lung cancer (NSCLC) being found in a BA lesion. Following surgery, the patient remains relapse-free. Key pointsSignificant findings of the study Pathological assessment of a lung nodule confirmed a papillary tumor with a double-layered cell structure, less than typical cytoplasm, and a mixture of ciliated columnar and globular cells, consistent with a distal-type bronchiolar adenoma. What this study adds This is the first report of anEGFR exon 21 p.L858Rmutation in a bronchiolar adenoma.
Engineering biomimetic graphene nanodecoys camouflaged with the EGFR/HEK293 cell membrane for targeted capture of drug leads
BIOMATERIALS SCIENCE
Authors: Hu, Qi; Zhang, Xiaolin; Jia, Lanlan; Zhen, Xueyan; Pan, Xiaoyan; Xie, Xiaoyu; Wang, Sicen
Abstract
Advanced graphene (G)-based nanomaterials have risen as emerging stars for biomedical applications over the past decade due to their unique physicochemical properties. However, the preparation of G-based nanomaterials with satisfactory bioactivity to meet the growing demands of multitasking applications in biocomplexity systems remains a challenge. Herein, we presented a biomimetic route to modify graphene oxide (GO) using high expression epidermal growth factor receptor cell membrane (CM). Owing to the inherent properties of the CM for multifaceted interaction with active ligands, the well camouflaged GO could capture the drug leads with targeting properties. The as-prepared CM-coated magnetic GO exhibited excellent binding properties, including good selectivity, high adsorption capacity, and suitable adsorption rates. In addition, by coupling this assay with mass spectrometry, two potential bioactive compounds, luteolin and caffeic acid, were screened fromTaraxacum mongolicum Hand.-Mazz.It is anticipated that this biomimetic approach can open new possibilities for the rational design of improved G-based biocomposites and extend their bioapplications.
COA
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