Batch dependent - please inquire should you have specific requirements
Buffer
20 mM HEPES, 250 mM NaCl, pH 8.0, 20% Glycerol
Preservative
None
Storage
Store at -80°C
Introduction
Alanyl-tRNA synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 108 kDa protein is an autoantigen recognized by PL-12 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that epitope spreading occurs in the autoimmune PL-12 response such that even antibodies to an isolated alanyl-tRNA molecule can develop
Keywords
Alanyl-tRNA Synthetase; AARS; PL-12; Antisynthetase syndrome; ASS
Citations
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