Mouse anti-Bungarus fasciatus ACHE monoclonal antibody, clone Fab410 targets Bungarus fasciatus acetylcholinesterase. The supplied structural record is associated with PDB 4QWW.
Binds the peripheral anionic-site Ω-loop and partially occludes the active-site gorge rather than occupying the catalytic triad. Inhibits BfAChE and EeAChE while leaving measurable residual catalysis. "Back-door" substrate-access interpretation is mechanistic and should not be treated as directly observed substrate trafficking.
Product-specific preparation, formulation, size, storage, and shipping conditions were not specified in the supplied source.
Summary
Specifications
Antibody Isotype
IgG
Clone
410
Conjugate
Unconjugated
Applications
Application Notes
Inhibition, IA, ELISA This antibody inhibits BfAChE and EeAChE while preserving measurable residual catalytic activity. It is applicable to studies of AChE inhibition, enzyme access, and peripheral-site mechanisms. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded
General Notes
Inhibits BfAChE and EeAChE while leaving measurable residual catalysis. "Back-door" substrate-access interpretation is mechanistic and should not be treated as directly observed substrate trafficking.
Target
Alternative Names
ACHE; acetylcholine acetylhydrolase
Citations
Publication ()
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