Anti-Human PMS2 monoclonal antibody (CABT-L2803)

Specifications


Host Species
Mouse
Antibody Isotype
IgG
Clone
JID523
Species Reactivity
Human
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: IHC: 1:100 - 1:200
Positive and negative controls should be simultaneously run with unknown specimens, as there are no conclusive characteristics to suggest instability of the antibody.
The prediluted antibody does not require any mixing, dilution, reconstitution, or titration; the antibody is ready-to-use and optimized for staining.
The concentrated antibody requires dilution in the optimized buffer, to the recommended working dilution range (as above).
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


PMS2 Mouse Mab on Duodenum

Target


Alternative Names
PMS2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae); PMSL2, postmeiotic segregation increased (S. cerevisiae) 2; mismatch repair endonuclease PMS2; H_DJ0042M02.9; HNPCC4
Entrez Gene ID
UniProt ID

Product Background


Pathway
BRCA1-associated genome surveillance complex (BASC); DNA Repair; Direct p53 effectors; Fanconi anemia pathway; Mismatch Repair; Mismatch repair; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Cohn, DE; Pavelka, JC; et al. Correlation between patient weight and defects in DNA mismatch repair: is this the link between an increased risk of previous cancer in thinner women with endometrial cancer?. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 18:136-140(2008).
Mojtahed, A; Schrijver, I; et al. A two-antibody mismatch repair protein immunohistochemistry screening approach for colorectal carcinomas, skin sebaceous tumors, and gynecologic tract carcinomas. MODERN PATHOLOGY 24:1004-1014(2011).

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