Anti-PMS2 polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to PMS2.

Conjugate

Application Notes

WB: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:200. & The optimal working dilution should be determined by the end user.

Alternative Names

PMS2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae); PMSL2; HNPCC4; PMS2CL; mismatch repair endonuclease PMS2; H_DJ0042M02.9; PMS1 protein homolog 2; DNA mismatch repair protein PMS2;

Entrez Gene ID

UniProt ID

Antigen Description

This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Pathway

BRCA1-associated genome surveillance complex (BASC); Fanconi anemia pathway;