CDKN1A blocking peptide (DAG-P1746)

Synthetic CDKN1A blocking peptide for BL Datasheet

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Specificity
Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.
Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Belongs to the CDI family.
Cellular Localization
Cytoplasm. Nucleus.
Alternative Names
The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.The C-terminal
Format
Liquid
Buffer
PBS with 100ug BSA 0.1% sodium azide
Storage
Store at +4°C. PBS with 100ug BSA 0.1% sodium azide
UniProt ID
Antigen Description
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]
Function
cyclin binding; cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; metal ion binding; protein binding; protein complex binding;
Synonyms
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; cyclin-dependent kinase inhibitor 1; DNA synthesis inhibitor; CDK-interacting protein 1; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6;

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