Product Overview
ESAT-6 Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 104 amino acids (1-95 a.a) having a total molecular mass of 11kDa.
The ESAT-6 fused to a 6 amino acid His-tag & purified by proprietary chromatographic techniques.
Target
M. tuberculosis ESAT6
Alternative Names
M. tuberculosis ESAT6; ESAT 6; M. tuberculosis; M. tuberculosis ESAT-6
Purity
Greater than 90.0% as determined by SDS-PAGE.
Buffer
20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Storage
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Introduction
Mycobacterium antigen ESAT-6 has been isolated from low molecular weight fractions of the shot-term-culture filtrate (ST-CF) and it can easily be detected in tuberculosis patients.
The export of ESAT-6 which is a potent T-cell antigen, and related proteins requires a dedicated secretory apparatus that is encoded by a group of genes, several of which also code for proteins that are recognized strongly by T cells. The ESAT-6 systems can consequently be considered as immunogenicity islands and there is mounting evidence that the equivalent genes are subject to selective pressure imposed by the immune system of the host.
Keywords
M. tuberculosis ESAT6; ESAT 6; M. tuberculosis; M. tuberculosis ESAT-6
Citations
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