Product Overview
Recombinant Mycobacterium Tuberculosis Early Secretory Target 6
Purity
>90% as determined by SDS-PAGE
Buffer
20 mM PB, 150 mM NaCl, pH7.4
Storage
2-8°C short term, -20°C long term
Introduction
Mycobacterium tuberculosis (MTB) is a pathogenic bacterial species in the family Mycobacteriaceae and the causative agent of most cases of tuberculosis (TB). First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface (primarily mycolic acid), which makes the cells impervious to Gram staining. Acid-fast detection techniques are used instead. The physiology of M. tuberculosis is highly aerobic and requires high levels of oxygen. Primarily a pathogen of the mammalian respiratory system, MTB infects the lungs. The most frequently used diagnostic methods for TB are the tuberculin skin test, acid-fast stain, and chest radiographs.
Antigen Description
ESAT-6, the 6 kDa early secretory antigenic target of Mycobacterium tuberculosis, is a secretory protein and potent T cell antigen. It is used in tuberculosis diagnosis by the whole blood interferon γ test QuantiFERON-TB Gold, in conjunction with CFP-10 a
Keywords
Mycobacterium tuberculosis; Early secretory target 6; ESAT6
Citations
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