Molecular Weight
app. 65 kDa
Alternative Names
ibuprofen; 2-(4-Isobutylphenyl)propanoic acid; Brufen; Motrin
Purity
chromatography, dialysis
Concentration
1 mg/mL, conjugation ratio is app. 1:10 - 1:40.
Preservative
0.05% sodium azide
Introduction
Ibuprofen from the now-outdated nomenclature iso-butyl-propanoic-phenolic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used for relief of symptoms of arthritis, fever, as an analgesic (pain reliever), especially where there is an inflammatory component, and dysmenorrhea. Ibuprofen is known to have an antiplatelet effect, though it is relatively mild and short-lived when compared with aspirin or other better-known antiplatelet drugs. In general, ibuprofen also acts as a vasodilator, having been shown to dilate coronary arteries and some other blood vessels. Ibuprofen is a core medicine in the World Health Organization's WHO Model List of Essential Medicines, which is a list of minimum medical needs for a basic healthcare system. Originally marketed as Brufen, ibuprofen is available under a variety of popular trademarks, including Motrin, Nurofen, Advil, and Nuprin.
Antigen Description
Ibuprofen, covalently linked to biotinylated human serum albumin
Keywords
drug-HSA-Biotin conjugate, drug-conjugate, Ibuprofen HSA-Biotin conjugate
Citations
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Chintalacharuvu, SR; Urankar-Nagy, N; et al. Treatment of collagen induced arthritis by proteolytic enzymes: Immunomodulatory and disease modifying effects. JOURNAL OF RHEUMATOLOGY 28:2049-2059(2001).
Udd, M; Miettinen, P; et al. Analysis of the risk factors and their combinations in acute gastroduodenal ulcer bleeding: A case-control study. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 42:1395-1403(2007).