Product Overview
C-terminal 6xHis tagged ectodomain of HA(H5N1) ( A/Egypt/N03072/2010 ) protein (a.a. 18-530)
Format
Each vial contains 100 μg of purified protein in PBS.
Storage
2-8°C short term, -20°C long term
Introduction
Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting
Antigen Description
Hemagglutinin (HA) is a single-pass type I integral membrane glycoprotein from the influenza virus, and comprises over 80% of the envelope proteins present in the virus particle. In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. Binding of HA to sialic acid-containing receptors on the surface of its target cell brings about the attachment of the virus particle to the cell and forms a endosome. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the hydrophobic portion "fusion peptide". After which, virus penetrates the cell and pours its contents including the RNA genome into the cytoplasm mediated by fusion of the endocytosed virus particle's own membrane and the endosomal membrane. Hemagglutinin plays a major role in the determination of host range restriction and virulence. HA is cleaved by tryptase clara which is restricted to lungs, and thus bud into lumen of lungs and are therefore usually pneumotropic. However, HAs of H5 and H7 pantropic avian viruses subtypes can be cleaved by furin and subtilisin-type enzymes, allowing the virus to grow in other organs than lungs.
Keywords
Influenzavirus A; Influenza A virus; Influenza A virus H5N1; H5N1; IAV H5N1
Citations
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