General Notes
This product (Catalog No. DMAB-CBAS090) is a mouse-derived monoclonal antibody raised against human POSTN. It has been affinity purified by Protein A. POSTN (periostin) is a matricellular protein that plays diverse roles in both physiological and pathological processes. It is involved in embryonic development, tissue repair, and maintenance of bone and connective tissues. However, abnormal upregulation of POSTN is associated with various diseases, particularly cancer and inflammatory conditions. In cancer, POSTN promotes tumor progression by enhancing cell proliferation, invasion, and metastasis through interactions with integrins and activation of signaling pathways like MAPK and PI3K/AKT. It also contributes to the tumor microenvironment by promoting angiogenesis and fibrosis. In inflammatory diseases such as asthma and fibrosis, POSTN interacts with cytokines and activates pathways like NF-κB, exacerbating inflammation and tissue remodeling. Additionally, POSTN has been implicated in cardiovascular diseases and intervertebral disc degeneration. Its multifaceted roles in disease progression make POSTN a potential biomarker and therapeutic target for various conditions.
DMAB-CBAS090 is suitable for use in ELISA(Cap) application.
DMAB-CBAS090 is supplied as a liquid formulation in Phosphate-buffered saline (PBS), carrier-free, with optional 0.09% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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