General Notes
This product (Catalog No. CABT-L1521W) is a rabbit-derived polyclonal antibody raised against human MC4R, targeting the amino acid region 306–332 of the protein. The Melanocortin-4 receptor (MC4R) is a class A G-protein-coupled receptor (GPCR) encoded by an intronless gene on chromosome 18q21.3, consisting of 332 amino acids organized into seven transmembrane domains, and it serves as a key regulator of energy homeostasis, appetite control, and body weight balance primarily through its expression in hypothalamic neurons. Encoded by a 999-base-pair gene, MC4R exhibits high evolutionary conservation, with 93% amino acid identity between human and rat sequences, underscoring its fundamental physiological role across species.
CABT-L1521W is suitable for use in ELISA application.
CABT-L1521W is supplied as a lyophilized formulation. Reconstitute with 100 μl of distilled water for the equivalent of undiluted antiserum. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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