Rabbit Anti-Human F10 (activated heavy chain,Cleaved-Ile235) polyclonal antibody

This paper deals with the interaction of nanoparticles (NPs) in transformer oil and water in the oil and its effect on the electrical properties of the nanoffuid (NF). The breakdown strength and dielectric spectrum measurements under AC for various concentrations of natural SiO2 and water in mineral oil were studied. Mineral oil-based SiO2 NFs exhibit significantly higher breakdown voltage than that of base oil under high water content. However, there is an optimal range of NP concentration and water content for maximum breakdown voltage. The results of dielectric spectrum indicate that the dielectric constants of NFs and base oil are greatly affected by water content. The real relative permittivity of oil samples increases exponentially with water content at decreasing frequency (f10 Hz). The imaginary relative permittivity of NFs is less than that of the base oil in all cases. Based the experimental results reported, a model on the interplay between NPs and water in transformer oil is presented. The model can broadly explain the influence of the coexistence of NPs and water on the dielectric properties of transformer oil.

To evaluate possibility as a skin whitening agent of Sorghum bicolor (S. bicolor), its antioxidant activity and anti-melanogenic effect on 3-isobutyl-1-methylxanthine (IBMX)-induced melanogenesis in B16/F10 melanoma cells were investigated. The result of total phenolic contents (TPC) indicated that 60% ethanol extract of S. bicolor (ESB) has the highest contents than other ethanol extracts. Antioxidant activity was evaluated using the 2,2'-azino-bis-(3-ethylbenzothiazolin-6-sulfonic acid) diammonium salt (ABTS)/1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activities and malondialdehyde (MDA) inhibitory effect. These results showed ESB has significant antioxidant activities. Inhibitory effect against tyrosinase was also assessed using L-tyrosine (IC50 value = 89.25 mu g/mL) and 3,4-dihydroxy-L-phenylalanine (L-DOPA) as substrates. In addition, ESB treatment effectively inhibited melanin production in IBMX-induced B16/F10 melanoma cells. To confirm the mechanism on anti-melanogenic effect of ESB, we examined melanogenesis-related proteins. ESB downregulated melanogenesis by decreasing expression of microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related protein (TRP)-1. Finally, 9-hydroxyoctadecadienoic acid (9-HODE), 1,3-O-dicaffeoylglycerol and tricin as the main compounds of ESB were analyzed using the ultra-performance liquid chromatography-ion mobility separation-quadrupole time of flight/tandem mass spectrometry (UPLC-IMS-QTOF/MS2). These findings suggest that ESB may have physiological potential to be used skin whitening material.