Abatacept Biosimilar (BSA and Azide free) suitable for Functional Assays
Target: Human CD80 (B7-1) / CD86 (B7-2)
Isotype: Human IgG1
Summary
Specifications
Antibody Isotype
IgG1
Clone
Abatacept
Species Reactivity
Human
Conjugate
Unconjugated
Applications
Application Notes
Functional Assays Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
General Notes
Abatacept (Orencia, Bristol-Myers-Squibb) is a fusion protein of a Fc fragment (human IgG1 isotype) and the extracellular domain of CTLA-4, can be used to extend graft survival while limiting the toxicity generated by standard immune suppressing regimens, such as calcineurin inhibitors. Abatacept binds to CD80 (B7-1) with more avidity than to CD86 (B7-2). It inhibits the costimulation of T cells. Abatacept differs from belatacept (trade name Nulojix) by only 2 amino acids.
Target
Alternative Names
Abatacept, Orencia, Bristol-Myers-Squibb
Citations
Publication ()
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