Prognostic Value ofCD200R1mRNA Expression in Head and Neck Squamous Cell Carcinoma
CANCERS
Authors: Chang, Hyun; Lee, Yun-Gyoo; Ko, Yoon Ho; Cho, Jang Ho; Choi, Jong-Kwon; Park, Keon Uk; Kang, Eun Joo; Lee, Keun-Wook; Lim, Sun Min; Kim, Jin-Soo; Lee, Hyun Woo; Kim, Min Kyoung; Hwang, In Gyu; Kim, Sangwoo; Nam, Byung-Ho; Kim, Hye Ryun
Abstract
Immune system dysfunction is associated with head and neck squamous cell carcinoma (HNSCC) development and progression and immune checkpoint inhibitors have demonstrated substantial survival benefits in platinum-refractory HNSCC; therefore, we examined the prognostic value of immune-related gene (IRG) expression in HNSCC. We analyzed the expression of 82 IRGs in 71 patients with HNSCC enrolled in a feasibility study for a prospective HNSCC biomarker-driven umbrella trial (Korean Cancer Study Group TRIUMPH study, NCT03292250).CD200R1was identified as an independent prognostic factor and validated in GEO and TCGA database.CD2000R1mRNA expression was found to be an independent favorable prognostic factor in patients with HNSCC. Moreover,CD200R1was found to affect genes and pathways associated with the immune response, while seven differentially expressed genes (CD8A, DOK2, CX3CR1, TYROBP, CXCL9, CD300LF, IFNG) were associated withCD200R1expression. Samples with higherCD200R1expression displayed higher tumor-infiltrating immune cell counts both in silico and in histological analysis. These findings will help in the development of more accurate prognostic tools and suggest CD200R1 modulation as a HNSCC immunotherapy.
Tropism for tuft cells determines immune promotion of norovirus pathogenesis
SCIENCE
Authors: Wilen, Craig B.; Lee, Sanghyun; Hsieh, Leon L.; Orchard, Robert C.; Desai, Chandni; Hykes, Barry L., Jr.; McAllaster, Michael R.; Balce, Dale R.; Feehley, Taylor; Brestoff, Jonathan R.; Hickey, Christina A.; Yokoyama, Christine C.; Wang, Ya-Ting; MacDuff, Donna A.; Kreamalmayer, Darren; Howitt, Michael R.; Neil, Jessica A.; Cadwell, Ken; Allen, Paul M.; Handley, Scott A.; Campagne, Menno van Lookeren; Baldridge, Megan T.; Virgin, Herbert W.
Abstract
Complex interactions between host immunity and the microbiome regulate norovirus infection. However, the mechanism of host immune promotion of enteric virus infection remains obscure. The cellular tropism of noroviruses is also unknown. Recently, we identified CD300lf as a murine norovirus (MNoV) receptor. In this study, we have shown that tuft cells, a rare type of intestinal epithelial cell, express CD300lf and are the target cell for MNoV in the mouse intestine. We found that type 2 cytokines, which induce tuft cell proliferation, promote MNoV infection in vivo. These cytokines can replace the effect of commensal microbiota in promoting virus infection. Our work thus provides insight into how the immune system and microbes can coordinately promote enteric viral infection.
COA
Publication 
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