Rabbit Anti-Human APP (Phospho-Thr743/668) polyclonal antibody

As the world becomes more urbanized and heavy precipitation events increase in frequency and intensity, urban (pluvial) flooding is an emerging concern. Recent advances in hydrologic and hydraulic modeling, high resolution quantitative precipitation forecasting, and ensemble forecasting have improved the ability to evaluate flash flooding potential in urban areas. The Probabilistic Urban Flash Flood Information Nexis (PUFFIN) app integrates these components into a tool to evaluate the probability of an urban flash flood event and to identify specific infrastructure components at risk. PUFFIN uses a combination of deterministic and probabilistic precipitation forecasts to provide analyses over a range of spatial and temporal resolutions. A case study for the City of Roanoke, Virginia in the United States demonstrates how PUFFIN can be used to assess the risk of urban flooding. However, with minimal modification, the application can be adapted for implementation in other locations.

Concerns are growing that exposure to environmental pollutants, such as traffic noise, might cause cognitive impairments and predispose individuals toward the development of Alzheimer's disease (AD) dementia. In this study in a knock-in mouse model of AD, we investigated how chronic traffic noise exposure (CTNE) impacts cognitive performance and amyloid-beta (A beta) pathology. A group of APP(NL-G-F/NL-G-F) mice was exposed to CTNE (70 dB(A), 8 hr/day for 1 month) and compared with nonexposed counterparts. Following CTNE, an increase in hypothalamic-pituitary-adrenal (HPA) axis responsivity was observed by corticosterone assay of the blood. One month after CTNE, the CTNE group demonstrated impairments in cognitive and motor functions, and indications of anxiety-like behavior, relative to the control animals. The noise-exposed group also showed elevated A beta aggregation, as inferred by a greater number of plaques and larger average plaque size in various regions of the brain, including regions involved in stress regulation. The results support that noise-associated dysregulation of the neuroendocrine system as a potential risk factor for developing cognitive impairment and A beta pathology, which should be further investigated in human studies.