Product Overview
Human alpha-Amyloid Precursor Protein (a.a 18-612) protein was expressed in HEK293 cells and fused to 10xHis at the N-terminus
Molecular Weight
69.2 kDa
Alternative Names
Amyloid Precursor Protein; APP; Beta-APP; Alpha-APP
Purity
> 95% , as determined by SDS-PAGE
Concentration
Batch dependent - please inquire should you have specific requirements.
Buffer
PBS with 20% glycerol
Storage
Store at -20°C to -80°C. Avoid multiple freeze/thaw cycles.
Introduction
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicated as a regulator of synapse formation, neural plasticity, antimicrobial activity, and iron export. It is coded for by the gene APP and regulated by substrate presentation. APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.
Keywords
APP; Amyloid-beta precursor protein; Alzheimer's disease
Citations
Publication ()
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