Anti-PAK1 Polyclonal Antibody (CABT-L2228) Knockout Validated

Rabbit Anti-Human PAK1 (Glu252~Cys501) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Rat
Immunogen
Recombinant fragment corresponding to human PAK1 (Glu252~Cys501)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.5-2 ug/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type Hela cell lysate. Lane 2: PAK1 knockout Hela cell lysate. Predicted MW: 61kd, Observed MW: 65kd
Figure. Western Blot. Sample. Lane1: Human Hela Cells; Lane2: Human Jurkat Cells; Lane3: Rat Brain Tissue.

Target


Alternative Names
PAKalpha; p65-PAK; p21/Cdc42/Rac1-Activated Kinase 1; Serine/threonine-protein kinase PAK 1
Entrez Gene ID
UniProt ID

Product Background


Pathway
Activation of Rac; Adaptive Immune System; Alpha6-Beta4 Integrin Signaling Pathway; Angiopoietin receptor Tie2-mediated signaling; Aurora A signaling; Axon guidance; CD28 co-stimulation; CD28 dependent Vav1 pathway;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Zhou, YW; Thomason, DB; et al. Binding of laminin alpha 1-chain LG4-5 domain to alpha-dystroglycan causes tyrosine phosphorylation of syntrophin to initiate Rac1 signaling. BIOCHEMISTRY 45:2042-2052(2006).
Sells, MA; Pfaff, A; et al. Temporal and spatial distribution of activated Pak1 in fibroblasts. JOURNAL OF CELL BIOLOGY 151:1449-1457(2000).

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