Aldosterone is a mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex. It plays a key role in regulating sodium and potassium homeostasis, blood pressure, and fluid balance by promoting sodium reabsorption and potassium excretion in the renal distal tubules and collecting ducts. Aldosterone acts through the mineralocorticoid receptor (MR), influencing gene transcription to modulate ion transporters and channels. Due to its well-defined steroid structure, physiological significance, and involvement in cardiovascular and renal function, aldosterone serves as an important reference compound in endocrinology, pharmacology, and studies of electrolyte and blood pressure regulation.
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