This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]
Function
SUMO binding; Toll-like receptor binding; interleukin-1, Type I receptor binding; kinase binding; protein binding; signal transducer activity; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding
Synonyms
TOLLIP; toll interacting protein; IL-1RAcPIP; toll-interacting protein; adapter protein
Citations
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