This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]
Pathway
Apoptosis Modulation and Signaling; Cytokine Signaling in Immune system; IL1-mediated signaling events; Immune System; Interleukin-1 signaling; Regulation of toll-like receptor signaling pathway; Signaling by Interleukins; Toll-like receptor signaling pathway
Citations
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