Human SNTA1 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-Syntrophin (alpha 1) antibody

Target

Syntrophin (alpha 1)

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]

Function

ATPase binding; PDZ domain binding; actin binding; calmodulin binding; ion channel binding; nitric-oxide synthase binding; protein binding; contributes_to sodium channel regulator activity;

Synonyms

SNTA1; syntrophin, alpha 1; SNT1; LQT12; TACIP1; dJ1187J4.5; alpha-1-syntrophin; syntrophin-1; acidic alpha 1 syntrophin; pro-TGF-alpha cytoplasmic domain-interacting protein 1; dystrophin-associated protein A1, 59kDa, acidic component; 59 kDa dystrophin-associated protein A1 acidic component 1; syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component);