Rabbit Anti-Human SNTA1 (N-terminal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

Synthetic peptide corresponding to residues near the N terminal of human syntrophin, alpha 1

Conjugate

Application Notes

IHC: 1:25-1:100

General Notes

This product (Catalog No. DPABH-27272) is a rabbit-derived polyclonal antibody raised against human SNTA1. This antibody exhibits cross-reactivity with SNTA1 from mouse. It has been affinity purified by Protein A. Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.
DPABH-27272 is suitable for use in IHC (1:25–1:100) application.
DPABH-27272 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

SNT1; LQT12; TACIP1; dJ1187J4.5

Entrez Gene ID

UniProt ID