This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]
Function
ATP binding; metal ion binding; poly(A) RNA binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity;
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