Anti-SMG1 monoclonal antibody, clone 2H6

Antibody Isotype

IgG1

Clone

2H6

Species Reactivity

Human

Immunogen

SMG1 (-, 2922 aa ~ 3032 aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

ATX; LIP; 61E3.4; KIAA0421; serine/threonine-protein kinase SMG1; OTTHUMP00000234388; lambda-interacting protein; PI-3-kinase-related kinase SMG-1; phosphatidylinositol 3-kinase-related kinase; lambda/iota protein kinase C-interacting protein; phosphatidylinositol 3-kinase-related protein kinase; SMG1 homolog, phosphatidylinositol 3-kinase-related kinase

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.Mouse monoclonal antibody raised against a partial recombinant SMG1.

Pathway

Metabolism of RNA, organism-specific biosystem; Metabolism of mRNA, organism-specific biosystem; Nonsense Mediated Decay Enhanced by the Exon Junction Complex, organism-specific biosystem; Nonsense-Mediated Decay, organism-specific biosystem; mRNA surveillance pathway, organism-specific biosystem; mRNA surveillance pathway, conserved biosystem