SNW1 blocking peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Concentration

200 μg/mL

Preservative

None

Storage

-20°C

Entrez Gene ID

Antigen Description

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. [provided by RefSeq, Jul 2008]

Function

Notch binding; SMAD binding; nuclear hormone receptor binding; poly(A) RNA binding; protein binding; retinoic acid receptor binding; transcription coactivator activity; transcription corepressor activity; vitamin D receptor binding

Synonyms

SNW1; SNW domain containing 1; Bx42; SKIP; Prp45; SKIIP; PRPF45; NCOA-62; SNW domain-containing protein 1; nuclear protein SkiP; SKI interacting protein; SKI-interacting protein; homolog of Drosophila BX42; nuclear receptor coactivator, 62-kD; nuclear receptor coactivator NCoA-62