Specifications
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 500 to the C-terminus of Human NCOA62.
Applications
Application Notes
ICC/IF: 1 μg/ml; WB: 1 mg/ml;
Target
Alternative Names
SNW1; SNW domain containing 1; Bx42; SKIP; Prp45; SKIIP; PRPF45; NCOA-62; SNW domain-containing protein 1; nuclear protein SkiP; SKI interacting protein; SKI-interacting protein; homolog of Drosophila BX42; nuclear receptor coactivator, 62-kD; nuclear rec
Product Background
Antigen Description
Nuclear receptor coactivator NCoA62 (Nuclear Protein SkiP, SKIIP , ski-interacting protein) is a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also interact with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
Pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Delta-Notch Signaling Pathway; Epstein-Barr virus infection; FBXW7 Mutants and NOTCH1 in Cancer
Citations
Publication ()
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COA
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