Anti-SNW1 (aa 1-110) polyclonal antibody

Species Reactivity

Human

Immunogen

SKIIP (NP_036377, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. The sequence is MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGD GGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDK

Conjugate

Alternative Names

SNW1; SNW domain containing 1; Bx42; SKIP; Prp45; SKIIP; PRPF45; NCOA-62; SNW domain-containing protein 1; nuclear protein SkiP; SKI interacting protein; SKI-interacting protein; homolog of Drosophila BX42; nuclear receptor coactivator, 62-kD; nuclear rec

Entrez Gene ID

UniProt ID

Antigen Description

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.

Pathway

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Delta-Notch Signaling Pathway; Epstein-Barr virus infection; FBXW7 Mutants and NOTCH1 in Cancer