This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]
Function
protein phosphatase binding; protein phosphatase regulator activity;
Synonyms
SHOC2; soc-2 suppressor of clear homolog (C. elegans); SOC2; SUR8; SIAA0862; leucine-rich repeat protein SHOC-2;
Citations
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