Human SF3B1 peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the SF3B1 family.Contains 11 HEAT repeats.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the introns branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Function

chromatin binding; poly(A) RNA binding; protein binding;

Synonyms

SF3B1; splicing factor 3b, subunit 1, 155kDa; MDS; PRP10; Hsh155; PRPF10; SAP155; SF3b155; splicing factor 3B subunit 1; SAP 155; pre-mRNA processing 10; spliceosome-associated protein 155; pre-mRNA splicing factor SF3b, 155 kDa subunit;