Anti-SF3B1 monoclonal antibody, clone FQS22098(C)

Antibody Isotype

IgG

Clone

FQS22098(C)

Species Reactivity

Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human SF3B1 (Cysteine residue).Database link: O75533

Conjugate

Application Notes

WB: 1/1000 - 1/10000; ICC/IF: 1/100 - 1/250; IHC-P: 1/100 - 1/250.

Alternative Names

SF3B1; splicing factor 3b, subunit 1, 155kDa; splicing factor 3b, subunit 1, 155kD; splicing factor 3B subunit 1; Hsh155; Prp10; PRPF10; SAP155; SF3b155; SAP 155; pre-mRNA processing 10; spliceosome associated protein 155; spliceosome-associated protein 1

Entrez Gene ID

UniProt ID

Antigen Description

SF3B1 is subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the introns branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures.

Pathway

Gene Expression, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; Spliceosome, organism-specific biosystem; Spliceosome, conserved biosystem; Spliceosome, U2-snRNP, organism-specific biosystem; mRNA Splicing, organism-specific biosystem; mRNA Splicing - Major Pathway, organism-specific biosystem;